Respiratory ß-2-Microglobulin exerts pH dependent antimicrobial activity
نویسندگان
چکیده
منابع مشابه
2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability
There is an urgent need to develop new drug treatment strategies to control the global spread of drug-sensitive and multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis). The ß-lactam class of antibiotics is among the safest and most widely prescribed antibiotics, but they are not effective against M. tuberculosis due to intrinsic resistance. This study shows that 2-aminoimidazole (2...
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Amyloid fibrils formed from unrelated proteins often share morphological similarities, suggesting common biophysical mechanisms for amyloidogenesis. Biochemical studies of human beta-2 microglobulin (beta2M) have shown that its transition from a water-soluble protein to insoluble aggregates can be triggered by low pH. Additionally, biophysical measurements of beta2M using NMR have identified re...
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Amyloidosis results from abnormal aggregation of native or proteolyzed proteins into amyloid fibrils [1] and is associated with an array of maladies, including Alzheimer’s Disease, Parkinson’s Disease, spongiform encephalopathies, type II diabetes and several forms of systemic amyloidosis [2, 3]. In each case, a protein or a proteolyzed fragment aggregates to form unbranched fibrils 10-20 nm wi...
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ژورنال
عنوان ژورنال: Virulence
سال: 2020
ISSN: 2150-5594,2150-5608
DOI: 10.1080/21505594.2020.1831367